By the 1950s 和in the 1950s 的区别在于 during the 1950s 可以么

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By the 1950s 和in the 1950s 的区别在于 during the 1950s 可以么

不可以,by...是一般用于完成时态,in...大多用于过去式,during也是用于过去式.